45. How high of a dose of doxycycline or tetracycline is needed for adults to allow the medications to be bactericidal instead of bacteriostatic?

The 'typical' doses (100 mg 2 X day) of Doxycycline that were prescribed by many doctors were not high enough to be considered bacteriostatic for Lyme disease. To enhance antibiotic action several other agents are now being prescribed along with the antibiotics in order to increase effectiveness. In addition, the recommendations for doxycycline doses now range from 300-600 mg a day. If necessary, doxycycline can be administered by IV to keep blood levels high.

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